1.3M XNAS Volume
XNAS 21 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Yung H. Chyung | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2025 | 44,000 | 44,000 | - | 0 | Common Stock | |
| Christopher Rovaldi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2025 | 60,000 | 60,000 | - | 0 | Common Stock | |
| Keith Regnante | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Feb 2025 | 44,000 | 44,000 | - | 0 | Common Stock | |
| Yung H. Chyung | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Nov 2024 | 110,000 | 110,000 | - | - | Employee Stock Option (right to buy) | |
| Carl L. Gordon | Director | Sale of securities on an exchange or to another person at price $ 44.01 per share. | 13 Aug 2024 | 29,400 | 119,522 | - | 44.0 | 1,293,894 | Common Stock |
| Carl L. Gordon | Director | Sale of securities on an exchange or to another person at price $ 44.01 per share. | 13 Aug 2024 | 220,600 | 899,212 | - | 44.0 | 9,708,606 | Common Stock |
| Jean-Jacques Bienaime | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 03 Jun 2024 | 17,600 | 17,600 | - | - | Stock Option (right to buy) | |
| Julius Knowles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Nima Farzan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Alpna Seth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Ran Nussbaum | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Tomer Kariv | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Carl L. Gordon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 30 May 2024 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Jasbir Seehra | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Feb 2024 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Regnante Keith | CHIEF FINANCIAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Jasbir Seehra | Director, CHIEF EXECUTIVE OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 125,000 | 125,000 | - | - | Employee Stock Option (right to buy) | |
| Christopher Rovaldi | CHIEF OPERATING OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 150,000 | 150,000 | - | - | Employee Stock Option (right to buy) | |
| Cooper Simon | CHIEF MEDICAL OFFICER | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Feb 2024 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Keith Regnante | CHIEF FINANCIAL OFFICER | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 04 Jan 2024 | 40,000 | 40,000 | - | 16 | 640,000 | Common Stock |
| Keith Regnante | CHIEF FINANCIAL OFFICER | Sale of securities on an exchange or to another person at price $ 45.29 per share. | 04 Jan 2024 | 40,000 | 0 | - | 45.3 | 1,811,600 | Common Stock |
| Keith Regnante | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.29 per share. | 04 Nov 2023 | 40,000 | 0 | - | 45.3 | 1,811,600 | Common Stock |
| Keith Regnante | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2023 | 40,000 | 53,622 | - | - | Employee Stock Option (right to buy) | |
| Keith Regnante | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 04 Nov 2023 | 40,000 | 40,000 | - | 16 | 640,000 | Common Stock |
| Keith Regnante | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 47.66 per share. | 08 Jun 2023 | 17,301 | 2,699 | - | 47.7 | 824,566 | Common Stock |
| Keith Regnante | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 48.65 per share. | 08 Jun 2023 | 2,699 | 0 | - | 48.6 | 131,306 | Common Stock |
| Keith Regnante | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 08 Jun 2023 | 20,000 | 20,000 | - | 16 | 320,000 | Common Stock |
| Keith Regnante | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 45.03 per share. | 08 Jun 2023 | 15,993 | 4,007 | - | 45.0 | 720,165 | Common Stock |
| Keith Regnante | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 46.46 per share. | 08 Jun 2023 | 1,428 | 2,579 | - | 46.5 | 66,345 | Common Stock |
| Keith Regnante | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 47.25 per share. | 08 Jun 2023 | 2,579 | 0 | - | 47.3 | 121,858 | Common Stock |
| Keith Regnante | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2023 | 20,000 | 113,622 | - | - | Employee Stock Option (right to buy) | |
| Keith Regnante | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jun 2023 | 20,000 | 93,622 | - | - | Employee Stock Option (right to buy) | |
| Keith Regnante | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 08 Jun 2023 | 20,000 | 20,000 | - | 16 | 320,000 | Common Stock |
| Alpna Seth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Ran Nussbaum | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Nima Farzan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Julius Knowles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Tomer Kariv | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Carl L. Gordon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2023 | 10,000 | 10,000 | - | - | Stock Option (right to buy) | |
| Alpna Seth | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2023 | 20,000 | 20,000 | - | - | Stock Option (right to buy) | |
| Jasbir Seehra | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Apr 2023 | 4,000 | 45,087 | - | - | Employee Stock Option (right to buy) | |
| Jasbir Seehra | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.48 per share. | 08 Apr 2023 | 4,000 | 252,856 | - | 0.5 | 1,920 | Common Stock |
| Keith Regnante | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Christopher Rovaldi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Jasbir Seehra | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 200,000 | 200,000 | - | - | Employee Stock Option (right to buy) | |
| Simon Cooper | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Feb 2023 | 40,000 | 40,000 | - | - | Employee Stock Option (right to buy) | |
| Tomer Kariv | Director, Ten Percent Owner | 29 Nov 2022 | 3,539 | 2,284,612 | - | 0 | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 29 Nov 2022 | 1,914 | 0 | - | - | Call Options (obligation to sell) | ||
| Tomer Kariv | Director, Ten Percent Owner | 29 Nov 2022 | 1,723 | 0 | - | - | Call Options (obligation to sell) | ||
| Tomer Kariv | Director, Ten Percent Owner | 29 Nov 2022 | 3,539 | 0 | - | - | Call Options (obligation to sell) | ||
| Tomer Kariv | Director, Ten Percent Owner | 29 Nov 2022 | 1,914 | 1,226,412 | - | 0 | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 29 Nov 2022 | 1,723 | 1,121,045 | - | 0 | Common Stock | ||
| Ran Nussbaum | Director, Ten Percent Owner | 29 Nov 2022 | 3,539 | 2,284,612 | - | 0 | Common Stock | ||
| Ran Nussbaum | Director, Ten Percent Owner | 29 Nov 2022 | 1,914 | 0 | - | - | Call Options (obligation to sell) | ||
| Ran Nussbaum | Director, Ten Percent Owner | 29 Nov 2022 | 1,723 | 0 | - | - | Call Options (obligation to sell) | ||
| Ran Nussbaum | Director, Ten Percent Owner | 29 Nov 2022 | 3,539 | 0 | - | - | Call Options (obligation to sell) | ||
| Ran Nussbaum | Director, Ten Percent Owner | 29 Nov 2022 | 1,914 | 1,226,412 | - | 0 | Common Stock | ||
| Ran Nussbaum | Director, Ten Percent Owner | 29 Nov 2022 | 1,723 | 1,121,045 | - | 0 | Common Stock | ||
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 15 Jul 2022 | 46,034 | 95,100 | - | 30 | 1,381,020 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jul 2022 | 46,034 | 8,755 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 15 Jul 2022 | 46,034 | 141,134 | - | 0.3 | 13,810 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 30.00 per share. | 13 Jul 2022 | 1,916 | 95,100 | - | 30 | 57,480 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Jul 2022 | 1,916 | 54,789 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 13 Jul 2022 | 1,916 | 93,184 | - | 0.3 | 575 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jun 2022 | 9,400 | 56,705 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 14 Jun 2022 | 9,400 | 95,100 | - | 0.3 | 2,820 | Common Stock |
| Jasbir Seehra | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 09 Jun 2022 | 5,000 | 248,856 | - | 0.3 | 1,500 | Common Stock |
| Jasbir Seehra | Director, Chief Executive Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Jun 2022 | 5,000 | 8,822 | - | - | Employee Stock Option (right to buy) | |
| Carl L. Gordon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 8,293 | 8,293 | - | - | Stock Options (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 8,293 | 8,293 | - | - | Stock Options (right to buy) | |
| Tomer Kariv | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 8,293 | 8,293 | - | - | Stock Options (right to buy) | |
| Ran Nussbaum | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 8,293 | 8,293 | - | - | Stock Options (right to buy) | |
| Nima Farzan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 8,293 | 8,293 | - | - | Stock Options (right to buy) | |
| Julius Knowles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2022 | 8,293 | 8,293 | - | - | Stock Options (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 43.32 per share. | 11 May 2022 | 719 | 85,939 | - | 43.3 | 31,147 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 42.49 per share. | 11 May 2022 | 944 | 86,658 | - | 42.5 | 40,111 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 41.26 per share. | 11 May 2022 | 3,398 | 87,602 | - | 41.3 | 140,201 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 May 2022 | 5,300 | 91,000 | - | 0.3 | 1,590 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2022 | 5,300 | 66,105 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 45.44 per share. | 11 May 2022 | 16 | 85,700 | - | 45.4 | 727 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 44.23 per share. | 11 May 2022 | 223 | 85,716 | - | 44.2 | 9,863 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 Apr 2022 | 5,300 | 91,000 | - | 0.3 | 1,590 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Apr 2022 | 5,300 | 71,405 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 64.15 per share. | 11 Apr 2022 | 559 | 85,700 | - | 64.2 | 35,860 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.50 per share. | 11 Apr 2022 | 2,315 | 86,259 | - | 63.5 | 147,003 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 62.32 per share. | 11 Apr 2022 | 1,009 | 88,574 | - | 62.3 | 62,881 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 61.37 per share. | 11 Apr 2022 | 1,417 | 89,583 | - | 61.4 | 86,961 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 06 Apr 2022 | 1,728 | 0 | - | 65 | 112,320 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Apr 2022 | 1,728 | 8,002 | - | - | Employee Stock Option (right to buy) | |
| Christopher Rovaldi | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 06 Apr 2022 | 1,728 | 1,728 | - | 16 | 27,648 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 04 Apr 2022 | 7,950 | 85,700 | - | 60 | 477,000 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Apr 2022 | 7,950 | 76,705 | - | - | of Shares Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 04 Apr 2022 | 7,950 | 93,650 | - | 0.3 | 2,385 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 56.20 per share. | 01 Apr 2022 | 104 | 758 | - | 56.2 | 5,845 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.00 per share. | 01 Apr 2022 | 864 | 864 | - | 16 | 13,824 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 54.50 per share. | 01 Apr 2022 | 2 | 862 | - | 54.5 | 109 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 56.89 per share. | 01 Apr 2022 | 287 | 471 | - | 56.9 | 16,327 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 57.97 per share. | 01 Apr 2022 | 366 | 105 | - | 58.0 | 21,217 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 58.83 per share. | 01 Apr 2022 | 105 | 0 | - | 58.8 | 6,177 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2022 | 864 | 9,730 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 Mar 2022 | 2,650 | 88,350 | - | 0.3 | 795 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2022 | 2,650 | 84,655 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.54 per share. | 11 Mar 2022 | 875 | 85,700 | - | 54.5 | 47,723 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 53.36 per share. | 11 Mar 2022 | 713 | 86,575 | - | 53.4 | 38,046 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.43 per share. | 11 Mar 2022 | 1,062 | 87,288 | - | 52.4 | 55,681 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 51.50 per share. | 11 Feb 2022 | 1,073 | 87,277 | - | 51.5 | 55,260 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2022 | 2,650 | 87,305 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 53.10 per share. | 11 Feb 2022 | 199 | 85,700 | - | 53.1 | 10,567 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.35 per share. | 11 Feb 2022 | 1,378 | 85,899 | - | 52.3 | 72,138 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 Feb 2022 | 2,650 | 88,350 | - | 0.3 | 795 | Common Stock |
| Christopher Rovaldi | Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Feb 2022 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Keith Regnante | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 50,000 | 50,000 | - | - | Employee Stock Option (right to buy) | |
| Jasbir Seehra | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 165,000 | 165,000 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 50,000 | 50,000 | - | - | Employee Stock Option (right to buy) | |
| Simon Cooper | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 Jan 2022 | 50,000 | 50,000 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.01 per share. | 11 Jan 2022 | 320 | 88,030 | - | 52.0 | 16,643 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jan 2022 | 2,650 | 89,955 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 54.45 per share. | 11 Jan 2022 | 1,134 | 85,700 | - | 54.4 | 61,746 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 53.56 per share. | 11 Jan 2022 | 1,196 | 86,834 | - | 53.6 | 64,058 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 Jan 2022 | 2,650 | 88,350 | - | 0.3 | 795 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 05 Jan 2022 | 2,650 | 85,700 | - | 60 | 159,000 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jan 2022 | 2,650 | 92,605 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 05 Jan 2022 | 2,650 | 88,350 | - | 0.3 | 795 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.99 per share. | 03 Jan 2022 | 4,151 | 347,383 | - | 58.0 | 240,716 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.83 per share. | 03 Jan 2022 | 3,318 | 245,812 | - | 57.8 | 191,880 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.96 per share. | 03 Jan 2022 | 5,236 | 356,408 | - | 59.0 | 308,715 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.00 per share. | 03 Jan 2022 | 435 | 232,727 | - | 59 | 25,665 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.00 per share. | 03 Jan 2022 | 667 | 341,574 | - | 59 | 39,353 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.20 per share. | 03 Jan 2022 | 886 | 233,162 | - | 58.2 | 51,565 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.20 per share. | 03 Jan 2022 | 1,356 | 342,241 | - | 58.2 | 78,919 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.23 per share. | 03 Jan 2022 | 271 | 234,048 | - | 57.2 | 15,509 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.23 per share. | 03 Jan 2022 | 419 | 343,597 | - | 57.2 | 23,979 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.86 per share. | 03 Jan 2022 | 2,195 | 234,319 | - | 58.9 | 129,198 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.86 per share. | 03 Jan 2022 | 3,367 | 344,016 | - | 58.9 | 198,182 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.99 per share. | 03 Jan 2022 | 2,704 | 236,514 | - | 58.0 | 156,805 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.82 per share. | 03 Jan 2022 | 3,678 | 366,738 | - | 56.8 | 208,984 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.95 per share. | 03 Jan 2022 | 1,113 | 239,218 | - | 56.9 | 63,385 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.95 per share. | 03 Jan 2022 | 1,707 | 351,534 | - | 57.0 | 97,214 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.10 per share. | 03 Jan 2022 | 1,383 | 240,331 | - | 56.1 | 77,586 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.10 per share. | 03 Jan 2022 | 2,124 | 353,241 | - | 56.1 | 119,156 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.95 per share. | 03 Jan 2022 | 524 | 241,714 | - | 55.0 | 28,794 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.95 per share. | 03 Jan 2022 | 794 | 355,365 | - | 54.9 | 43,630 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.40 per share. | 03 Jan 2022 | 162 | 242,238 | - | 59.4 | 9,623 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.82 per share. | 03 Jan 2022 | 2,406 | 249,130 | - | 56.8 | 136,709 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.83 per share. | 03 Jan 2022 | 5,094 | 361,644 | - | 57.8 | 294,586 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.40 per share. | 03 Jan 2022 | 249 | 356,159 | - | 59.4 | 14,791 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.96 per share. | 03 Jan 2022 | 3,412 | 242,400 | - | 59.0 | 201,172 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 13 Dec 2021 | 1,915 | 87,615 | - | 0.3 | 575 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2021 | 735 | 95,255 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 13 Dec 2021 | 1,915 | 95,990 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 13 Dec 2021 | 735 | 85,700 | - | 50 | 36,750 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 13 Dec 2021 | 735 | 86,435 | - | 0.3 | 221 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 53.57 per share. | 13 Dec 2021 | 7 | 85,700 | - | 53.6 | 375 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 52.22 per share. | 13 Dec 2021 | 390 | 85,707 | - | 52.2 | 20,366 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.11 per share. | 13 Dec 2021 | 1,518 | 86,097 | - | 50.1 | 76,067 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.99 per share. | 01 Dec 2021 | 79 | 385,673 | - | 52.0 | 4,107 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.27 per share. | 01 Dec 2021 | 1,021 | 261,538 | - | 56.3 | 57,452 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.27 per share. | 01 Dec 2021 | 1,566 | 385,752 | - | 56.3 | 88,119 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 55.71 per share. | 01 Dec 2021 | 1,649 | 262,559 | - | 55.7 | 91,866 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 55.71 per share. | 01 Dec 2021 | 2,528 | 387,318 | - | 55.7 | 140,835 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.67 per share. | 01 Dec 2021 | 3,372 | 264,208 | - | 54.7 | 184,347 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.67 per share. | 01 Dec 2021 | 5,168 | 389,846 | - | 54.7 | 282,535 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.48 per share. | 01 Dec 2021 | 4,243 | 395,014 | - | 53.5 | 226,916 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.48 per share. | 01 Dec 2021 | 2,766 | 267,580 | - | 53.5 | 147,926 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.67 per share. | 01 Dec 2021 | 90 | 251,536 | - | 54.7 | 4,920 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.67 per share. | 01 Dec 2021 | 138 | 370,416 | - | 54.7 | 7,544 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.86 per share. | 01 Dec 2021 | 5,705 | 251,626 | - | 53.9 | 307,271 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.86 per share. | 01 Dec 2021 | 8,747 | 370,554 | - | 53.9 | 471,113 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.17 per share. | 01 Dec 2021 | 4,155 | 257,331 | - | 53.2 | 220,921 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.17 per share. | 01 Dec 2021 | 6,372 | 379,301 | - | 53.2 | 338,799 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 52.00 per share. | 01 Dec 2021 | 52 | 261,486 | - | 52 | 2,704 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 60.00 per share. | 10 Nov 2021 | 15,900 | 85,700 | - | 60 | 954,000 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2021 | 5,300 | 97,905 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 Nov 2021 | 15,900 | 103,205 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 59.78 per share. | 10 Nov 2021 | 4,561 | 85,700 | - | 59.8 | 272,657 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 58.73 per share. | 10 Nov 2021 | 739 | 90,261 | - | 58.7 | 43,401 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 10 Nov 2021 | 5,300 | 91,000 | - | 0.3 | 1,590 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 10 Nov 2021 | 15,900 | 101,600 | - | 0.3 | 4,770 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 04 Nov 2021 | 10,600 | 85,700 | - | 50 | 530,000 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Nov 2021 | 10,600 | 119,105 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 04 Nov 2021 | 10,600 | 96,300 | - | 0.3 | 3,180 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.85 per share. | 01 Nov 2021 | 7,057 | 421,041 | - | 41.8 | 295,335 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.45 per share. | 01 Nov 2021 | 2,346 | 270,346 | - | 42.5 | 99,588 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.45 per share. | 01 Nov 2021 | 3,597 | 399,257 | - | 42.5 | 152,693 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.65 per share. | 01 Nov 2021 | 3,957 | 272,692 | - | 41.6 | 164,809 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.65 per share. | 01 Nov 2021 | 6,067 | 402,854 | - | 41.7 | 252,691 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 43.04 per share. | 01 Nov 2021 | 991 | 276,649 | - | 43.0 | 42,653 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 43.04 per share. | 01 Nov 2021 | 1,518 | 408,921 | - | 43.0 | 65,335 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Nov 2021 | 2,120 | 277,640 | - | 42.1 | 89,252 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Nov 2021 | 3,252 | 410,439 | - | 42.1 | 136,909 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.43 per share. | 01 Nov 2021 | 4,797 | 279,760 | - | 42.4 | 203,537 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.43 per share. | 01 Nov 2021 | 7,350 | 413,691 | - | 42.4 | 311,861 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.85 per share. | 01 Nov 2021 | 4,599 | 284,557 | - | 41.8 | 192,468 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.05 per share. | 19 Oct 2021 | 1,323 | 291,227 | - | 38.0 | 50,340 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.31 per share. | 19 Oct 2021 | 1,463 | 289,156 | - | 38.3 | 56,048 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.31 per share. | 19 Oct 2021 | 2,242 | 428,098 | - | 38.3 | 85,891 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 37.55 per share. | 19 Oct 2021 | 148 | 290,619 | - | 37.5 | 5,557 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 37.55 per share. | 19 Oct 2021 | 229 | 430,340 | - | 37.6 | 8,599 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.49 per share. | 19 Oct 2021 | 460 | 290,767 | - | 38.5 | 17,705 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.49 per share. | 19 Oct 2021 | 704 | 430,569 | - | 38.5 | 27,097 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.05 per share. | 19 Oct 2021 | 2,029 | 431,273 | - | 38.0 | 77,203 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.13 per share. | 14 Oct 2021 | 2,653 | 446,608 | - | 40.1 | 106,465 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.47 per share. | 14 Oct 2021 | 60 | 292,550 | - | 38.5 | 2,308 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.46 per share. | 14 Oct 2021 | 92 | 433,302 | - | 38.5 | 3,538 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 37.69 per share. | 14 Oct 2021 | 5,382 | 292,610 | - | 37.7 | 202,848 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 37.69 per share. | 14 Oct 2021 | 8,252 | 433,394 | - | 37.7 | 311,018 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.60 per share. | 14 Oct 2021 | 60 | 297,992 | - | 40.6 | 2,436 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.60 per share. | 14 Oct 2021 | 92 | 441,646 | - | 40.6 | 3,735 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 39.44 per share. | 14 Oct 2021 | 1,199 | 298,052 | - | 39.4 | 47,289 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 39.44 per share. | 14 Oct 2021 | 1,839 | 441,738 | - | 39.4 | 72,530 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.95 per share. | 14 Oct 2021 | 1,977 | 299,251 | - | 38.9 | 77,004 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 38.95 per share. | 14 Oct 2021 | 3,031 | 443,577 | - | 38.9 | 118,057 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.13 per share. | 14 Oct 2021 | 1,730 | 301,228 | - | 40.1 | 69,425 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.16 per share. | 01 Oct 2021 | 3,827 | 453,112 | - | 40.2 | 153,692 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.03 per share. | 01 Oct 2021 | 1,033 | 302,958 | - | 40.0 | 41,351 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.03 per share. | 01 Oct 2021 | 1,584 | 449,261 | - | 40.0 | 63,408 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.06 per share. | 01 Oct 2021 | 1,479 | 303,991 | - | 40.1 | 59,249 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.06 per share. | 01 Oct 2021 | 2,267 | 450,845 | - | 40.1 | 90,816 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.16 per share. | 01 Oct 2021 | 2,496 | 305,470 | - | 40.2 | 100,239 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.29 per share. | 27 Sep 2021 | 6,532 | 307,966 | - | 42.3 | 276,238 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.29 per share. | 27 Sep 2021 | 10,018 | 456,939 | - | 42.3 | 423,661 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.52 per share. | 27 Sep 2021 | 13,233 | 314,498 | - | 41.5 | 549,434 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.52 per share. | 27 Sep 2021 | 20,292 | 466,957 | - | 41.5 | 842,524 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.51 per share. | 27 Sep 2021 | 17,854 | 327,731 | - | 40.5 | 723,266 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 40.51 per share. | 27 Sep 2021 | 27,373 | 487,249 | - | 40.5 | 1,108,880 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2021 | 1,293 | 0 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 17 Aug 2021 | 1,293 | 85,700 | - | 0.3 | 388 | Common Stock |
| Simon Cooper | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Aug 2021 | 60,000 | 60,000 | - | - | Employee Stock Option (right to buy) | |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.22 per share. | 01 Jul 2021 | 13,268 | 530,196 | - | 41.2 | 546,907 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.22 per share. | 01 Jul 2021 | 8,650 | 355,745 | - | 41.2 | 356,553 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.72 per share. | 01 Jul 2021 | 3,776 | 345,585 | - | 41.7 | 157,535 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.72 per share. | 01 Jul 2021 | 5,789 | 514,622 | - | 41.7 | 241,517 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.08 per share. | 01 Jul 2021 | 5,626 | 349,361 | - | 41.1 | 231,116 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.08 per share. | 01 Jul 2021 | 8,627 | 520,411 | - | 41.1 | 354,397 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.77 per share. | 01 Jul 2021 | 30 | 354,987 | - | 42.8 | 1,283 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 42.76 per share. | 01 Jul 2021 | 46 | 529,038 | - | 42.8 | 1,967 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.89 per share. | 01 Jul 2021 | 728 | 355,017 | - | 41.9 | 30,496 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 41.89 per share. | 01 Jul 2021 | 1,112 | 529,084 | - | 41.9 | 46,582 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 Jun 2021 | 6,500 | 1,293 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 24 Jun 2021 | 6,500 | 84,407 | - | 0.3 | 1,950 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 50.02 per share. | 04 Jun 2021 | 870 | 548,290 | - | 50.0 | 43,517 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.46 per share. | 04 Jun 2021 | 560 | 364,395 | - | 51.5 | 28,818 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.46 per share. | 04 Jun 2021 | 858 | 543,464 | - | 51.5 | 44,153 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 50.80 per share. | 04 Jun 2021 | 2,586 | 364,955 | - | 50.8 | 131,369 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 50.80 per share. | 04 Jun 2021 | 3,968 | 544,322 | - | 50.8 | 201,574 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 50.02 per share. | 04 Jun 2021 | 568 | 367,541 | - | 50.0 | 28,411 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.76 per share. | 04 Jun 2021 | 366 | 368,109 | - | 48.8 | 17,846 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.76 per share. | 04 Jun 2021 | 560 | 549,160 | - | 48.8 | 27,306 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 47.34 per share. | 04 Jun 2021 | 512 | 368,475 | - | 47.3 | 24,238 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 47.34 per share. | 04 Jun 2021 | 786 | 549,720 | - | 47.3 | 37,209 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 46.48 per share. | 04 Jun 2021 | 459 | 368,987 | - | 46.5 | 21,334 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 46.48 per share. | 04 Jun 2021 | 703 | 550,506 | - | 46.5 | 32,675 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.15 per share. | 04 Jun 2021 | 663 | 369,446 | - | 48.1 | 31,923 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.15 per share. | 04 Jun 2021 | 1,018 | 551,209 | - | 48.2 | 49,017 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 47.23 per share. | 04 Jun 2021 | 1,950 | 370,109 | - | 47.2 | 92,099 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 47.23 per share. | 04 Jun 2021 | 2,988 | 552,227 | - | 47.2 | 141,123 | Common Stock |
| Carl L Gordon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2021 | 8,293 | 8,293 | - | - | Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2021 | 8,293 | 8,293 | - | - | Stock Option (right to buy) | |
| Tomer Kariv | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2021 | 8,293 | 8,293 | - | - | Stock Option (right to buy) | |
| Ran Nussbaum | Director, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2021 | 8,293 | 8,293 | - | - | Stock Option (right to buy) | |
| Nima Farzan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2021 | 8,293 | 8,293 | - | - | Stock Option (right to buy) | |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.45 per share. | 01 Jun 2021 | 138 | 559,994 | - | 51.4 | 7,100 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 50.52 per share. | 01 Jun 2021 | 361 | 375,266 | - | 50.5 | 18,238 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 50.52 per share. | 01 Jun 2021 | 553 | 560,132 | - | 50.5 | 27,938 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 49.26 per share. | 01 Jun 2021 | 874 | 375,627 | - | 49.3 | 43,053 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 49.26 per share. | 01 Jun 2021 | 1,343 | 560,685 | - | 49.3 | 66,156 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.35 per share. | 01 Jun 2021 | 3,225 | 376,501 | - | 48.4 | 155,929 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.35 per share. | 01 Jun 2021 | 4,944 | 562,028 | - | 48.3 | 239,042 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.15 per share. | 01 Jun 2021 | 1,903 | 372,059 | - | 48.1 | 91,629 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.63 per share. | 01 Jun 2021 | 46 | 566,972 | - | 54.6 | 2,513 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.77 per share. | 01 Jun 2021 | 414 | 379,756 | - | 53.8 | 22,261 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.77 per share. | 01 Jun 2021 | 633 | 567,018 | - | 53.8 | 34,036 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 52.72 per share. | 01 Jun 2021 | 1,531 | 380,170 | - | 52.7 | 80,714 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 52.72 per share. | 01 Jun 2021 | 2,345 | 567,651 | - | 52.7 | 123,628 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.90 per share. | 01 Jun 2021 | 1,504 | 381,701 | - | 51.9 | 78,058 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.90 per share. | 01 Jun 2021 | 2,309 | 569,996 | - | 51.9 | 119,837 | Common Stock |
| Julius Knowles | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2021 | 8,293 | 8,293 | - | - | Stock Option (right to buy) | |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.63 per share. | 01 Jun 2021 | 30 | 379,726 | - | 54.6 | 1,639 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 48.15 per share. | 01 Jun 2021 | 2,917 | 555,215 | - | 48.2 | 140,454 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 47.69 per share. | 01 Jun 2021 | 1,213 | 373,962 | - | 47.7 | 57,848 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 47.69 per share. | 01 Jun 2021 | 1,862 | 558,132 | - | 47.7 | 88,799 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 51.45 per share. | 01 Jun 2021 | 91 | 375,175 | - | 51.5 | 4,682 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.11 per share. | 11 May 2021 | 6,220 | 77,407 | - | 0.1 | 684 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 May 2021 | 2,650 | 73,837 | - | 0.3 | 795 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 2,650 | 132,355 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 May 2021 | 500 | 77,907 | - | 0.3 | 150 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 11 May 2021 | 2,650 | 71,187 | - | 50 | 132,500 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 500 | 7,793 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 6,220 | 0 | - | - | Employee Stock Option (right to buy) | |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 May 2021 | 1,000 | 99,211 | - | - | Employee Stock Option (right to buy) | |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 50.15 per share. | 11 May 2021 | 1,000 | 0 | - | 50.2 | 50,150 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.48 per share. | 11 May 2021 | 1,000 | 1,000 | - | 0.5 | 480 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.63 per share. | 03 May 2021 | 6,841 | 588,922 | - | 56.6 | 387,406 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.04 per share. | 03 May 2021 | 5,383 | 595,763 | - | 56.0 | 301,663 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.04 per share. | 03 May 2021 | 3,509 | 398,506 | - | 56.0 | 196,644 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.63 per share. | 03 May 2021 | 4,460 | 394,046 | - | 56.6 | 252,570 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.86 per share. | 03 May 2021 | 7,054 | 581,868 | - | 57.9 | 408,144 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.86 per share. | 03 May 2021 | 4,600 | 389,446 | - | 57.9 | 266,156 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.78 per share. | 03 May 2021 | 6,905 | 574,963 | - | 58.8 | 405,876 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.78 per share. | 03 May 2021 | 4,506 | 384,940 | - | 58.8 | 264,863 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.48 per share. | 03 May 2021 | 942 | 574,021 | - | 59.5 | 56,030 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.48 per share. | 03 May 2021 | 616 | 384,324 | - | 59.5 | 36,640 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.73 per share. | 03 May 2021 | 1,196 | 572,825 | - | 53.7 | 64,261 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 53.73 per share. | 03 May 2021 | 780 | 383,544 | - | 53.7 | 41,909 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.35 per share. | 03 May 2021 | 520 | 572,305 | - | 54.4 | 28,262 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.35 per share. | 03 May 2021 | 339 | 383,205 | - | 54.4 | 18,425 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 61.72 per share. | 12 Apr 2021 | 100 | 71,187 | - | 61.7 | 6,172 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 61.08 per share. | 12 Apr 2021 | 729 | 71,287 | - | 61.1 | 44,527 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 59.99 per share. | 12 Apr 2021 | 3,473 | 72,016 | - | 60.0 | 208,345 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 59.10 per share. | 12 Apr 2021 | 998 | 75,489 | - | 59.1 | 58,982 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 12 Apr 2021 | 5,300 | 76,487 | - | 0.3 | 1,590 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 5,300 | 135,005 | - | - | Employee Stock Option (right to buy) | |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 60.01 per share. | 12 Apr 2021 | 367 | 233 | - | 60.0 | 22,024 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Apr 2021 | 1,000 | 100,211 | - | - | Employee Stock Option (right to buy) | |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 59.09 per share. | 12 Apr 2021 | 400 | 600 | - | 59.1 | 23,636 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.48 per share. | 12 Apr 2021 | 1,000 | 1,000 | - | 0.5 | 480 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 61.23 per share. | 12 Apr 2021 | 233 | 0 | - | 61.2 | 14,267 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.22 per share. | 06 Apr 2021 | 1,233 | 404,452 | - | 58.2 | 71,785 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.22 per share. | 06 Apr 2021 | 1,889 | 604,885 | - | 58.2 | 109,978 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.94 per share. | 06 Apr 2021 | 35 | 402,015 | - | 59.9 | 2,098 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.94 per share. | 06 Apr 2021 | 54 | 601,146 | - | 59.9 | 3,237 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.10 per share. | 06 Apr 2021 | 2,402 | 402,050 | - | 59.1 | 141,958 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.10 per share. | 06 Apr 2021 | 3,685 | 601,200 | - | 59.1 | 217,784 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.11 per share. | 01 Apr 2021 | 9,996 | 71,187 | - | 0.1 | 1,100 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Apr 2021 | 9,996 | 0 | - | - | Employee Stock Option (right to buy) | |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.66 per share. | 01 Apr 2021 | 298 | 622,909 | - | 58.7 | 17,481 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.26 per share. | 01 Apr 2021 | 6,972 | 405,685 | - | 60.3 | 420,133 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.26 per share. | 01 Apr 2021 | 10,690 | 606,774 | - | 60.3 | 644,179 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.76 per share. | 01 Apr 2021 | 3,551 | 412,657 | - | 59.8 | 212,208 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.76 per share. | 01 Apr 2021 | 5,445 | 617,464 | - | 59.8 | 325,393 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.66 per share. | 01 Apr 2021 | 195 | 416,208 | - | 58.7 | 11,439 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.36 per share. | 01 Apr 2021 | 134 | 416,403 | - | 61.4 | 8,222 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.36 per share. | 01 Apr 2021 | 206 | 623,207 | - | 61.4 | 12,640 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.82 per share. | 01 Apr 2021 | 283 | 416,537 | - | 60.8 | 17,212 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.82 per share. | 01 Apr 2021 | 434 | 623,413 | - | 60.8 | 26,396 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.08 per share. | 01 Apr 2021 | 1,533 | 416,820 | - | 59.1 | 90,570 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.08 per share. | 01 Apr 2021 | 2,350 | 623,847 | - | 59.1 | 138,838 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.42 per share. | 01 Apr 2021 | 2,472 | 418,353 | - | 58.4 | 144,414 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.42 per share. | 01 Apr 2021 | 3,790 | 626,197 | - | 58.4 | 221,412 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 Mar 2021 | 5,300 | 66,491 | - | 0.3 | 1,590 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2021 | 5,300 | 140,305 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 65.50 per share. | 11 Mar 2021 | 4 | 61,191 | - | 65.5 | 262 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 64.72 per share. | 11 Mar 2021 | 3,557 | 61,195 | - | 64.7 | 230,209 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.99 per share. | 11 Mar 2021 | 1,739 | 64,752 | - | 64.0 | 111,279 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.09 per share. | 11 Mar 2021 | 395 | 605 | - | 64.1 | 25,316 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Mar 2021 | 1,000 | 101,211 | - | - | Employee Stock Option (right to buy) | |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.86 per share. | 11 Mar 2021 | 605 | 0 | - | 64.9 | 39,240 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.48 per share. | 11 Mar 2021 | 1,000 | 1,000 | - | 0.5 | 480 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.22 per share. | 03 Mar 2021 | 1,086 | 424,331 | - | 54.2 | 58,883 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 54.22 per share. | 03 Mar 2021 | 1,662 | 635,365 | - | 54.2 | 90,114 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.88 per share. | 03 Mar 2021 | 496 | 425,417 | - | 58.9 | 29,204 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.88 per share. | 03 Mar 2021 | 761 | 637,027 | - | 58.9 | 44,808 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.79 per share. | 03 Mar 2021 | 1,894 | 425,913 | - | 57.8 | 109,454 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.79 per share. | 03 Mar 2021 | 2,903 | 637,788 | - | 57.8 | 167,764 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.95 per share. | 03 Mar 2021 | 1,958 | 427,807 | - | 56.9 | 111,508 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.95 per share. | 03 Mar 2021 | 3,004 | 640,691 | - | 57.0 | 171,078 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 55.91 per share. | 03 Mar 2021 | 793 | 643,695 | - | 55.9 | 44,337 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 55.91 per share. | 03 Mar 2021 | 518 | 429,765 | - | 55.9 | 28,961 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.03 per share. | 03 Mar 2021 | 126 | 420,825 | - | 58.0 | 7,312 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.03 per share. | 03 Mar 2021 | 193 | 629,987 | - | 58.0 | 11,200 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.21 per share. | 03 Mar 2021 | 553 | 420,951 | - | 57.2 | 31,637 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.21 per share. | 03 Mar 2021 | 847 | 630,180 | - | 57.2 | 48,457 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.18 per share. | 03 Mar 2021 | 895 | 421,504 | - | 56.2 | 50,281 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 56.18 per share. | 03 Mar 2021 | 1,376 | 631,027 | - | 56.2 | 77,304 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 55.21 per share. | 03 Mar 2021 | 1,932 | 422,399 | - | 55.2 | 106,666 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 55.21 per share. | 03 Mar 2021 | 2,962 | 632,403 | - | 55.2 | 163,532 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 64.09 per share. | 01 Mar 2021 | 406 | 435,536 | - | 64.1 | 26,021 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.90 per share. | 01 Mar 2021 | 90 | 430,283 | - | 61.9 | 5,571 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.90 per share. | 01 Mar 2021 | 138 | 644,488 | - | 61.9 | 8,542 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.61 per share. | 01 Mar 2021 | 361 | 430,373 | - | 60.6 | 21,880 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.61 per share. | 01 Mar 2021 | 554 | 644,626 | - | 60.6 | 33,578 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.05 per share. | 01 Mar 2021 | 686 | 430,734 | - | 60.0 | 41,194 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.05 per share. | 01 Mar 2021 | 1,052 | 645,180 | - | 60.1 | 63,173 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.90 per share. | 01 Mar 2021 | 714 | 431,420 | - | 58.9 | 42,055 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.90 per share. | 01 Mar 2021 | 1,095 | 646,232 | - | 58.9 | 64,496 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.93 per share. | 01 Mar 2021 | 2,377 | 432,134 | - | 57.9 | 137,700 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 57.93 per share. | 01 Mar 2021 | 3,644 | 647,327 | - | 57.9 | 211,097 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 67.60 per share. | 01 Mar 2021 | 30 | 434,511 | - | 67.6 | 2,028 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 67.61 per share. | 01 Mar 2021 | 46 | 650,971 | - | 67.6 | 3,110 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 66.04 per share. | 01 Mar 2021 | 516 | 434,541 | - | 66.0 | 34,077 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 66.04 per share. | 01 Mar 2021 | 792 | 651,017 | - | 66.0 | 52,304 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 65.28 per share. | 01 Mar 2021 | 479 | 435,057 | - | 65.3 | 31,269 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 65.29 per share. | 01 Mar 2021 | 734 | 651,809 | - | 65.3 | 47,923 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 64.09 per share. | 01 Mar 2021 | 625 | 652,543 | - | 64.1 | 40,056 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.22 per share. | 01 Mar 2021 | 1,169 | 435,942 | - | 63.2 | 73,904 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.22 per share. | 01 Mar 2021 | 1,794 | 653,168 | - | 63.2 | 113,417 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.11 per share. | 01 Mar 2021 | 1,473 | 437,111 | - | 62.1 | 91,488 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.11 per share. | 01 Mar 2021 | 2,257 | 654,962 | - | 62.1 | 140,182 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.33 per share. | 01 Mar 2021 | 1,050 | 438,584 | - | 61.3 | 64,397 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.33 per share. | 01 Mar 2021 | 1,608 | 657,219 | - | 61.3 | 98,619 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.11 per share. | 26 Feb 2021 | 33,200 | 61,191 | - | 0.1 | 3,652 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Feb 2021 | 33,200 | 9,996 | - | - | Employee Stock Option (right to buy) | |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 65.02 per share. | 16 Feb 2021 | 116 | 658,827 | - | 65.0 | 7,542 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 64.17 per share. | 16 Feb 2021 | 552 | 439,709 | - | 64.2 | 35,422 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 64.16 per share. | 16 Feb 2021 | 845 | 658,943 | - | 64.2 | 54,215 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.04 per share. | 16 Feb 2021 | 205 | 440,261 | - | 63.0 | 12,923 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.04 per share. | 16 Feb 2021 | 315 | 659,788 | - | 63.0 | 19,858 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.68 per share. | 16 Feb 2021 | 180 | 440,466 | - | 61.7 | 11,102 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.68 per share. | 16 Feb 2021 | 276 | 660,103 | - | 61.7 | 17,024 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.06 per share. | 16 Feb 2021 | 150 | 440,646 | - | 60.1 | 9,009 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.06 per share. | 16 Feb 2021 | 230 | 660,379 | - | 60.1 | 13,814 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.72 per share. | 16 Feb 2021 | 1,705 | 440,796 | - | 62.7 | 106,938 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.72 per share. | 16 Feb 2021 | 2,613 | 660,609 | - | 62.7 | 163,887 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.80 per share. | 16 Feb 2021 | 1,201 | 442,501 | - | 61.8 | 74,222 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.80 per share. | 16 Feb 2021 | 1,841 | 663,222 | - | 61.8 | 113,774 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.66 per share. | 16 Feb 2021 | 764 | 443,702 | - | 60.7 | 46,344 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.66 per share. | 16 Feb 2021 | 1,173 | 665,063 | - | 60.7 | 71,154 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.96 per share. | 16 Feb 2021 | 2,249 | 444,466 | - | 60.0 | 134,850 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.96 per share. | 16 Feb 2021 | 3,449 | 666,236 | - | 60.0 | 206,802 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.74 per share. | 16 Feb 2021 | 421 | 446,715 | - | 58.7 | 24,730 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.74 per share. | 16 Feb 2021 | 645 | 669,685 | - | 58.7 | 37,887 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.92 per share. | 16 Feb 2021 | 90 | 447,136 | - | 60.9 | 5,483 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.92 per share. | 16 Feb 2021 | 138 | 670,330 | - | 60.9 | 8,407 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.23 per share. | 16 Feb 2021 | 2,609 | 447,226 | - | 60.2 | 157,140 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.23 per share. | 16 Feb 2021 | 3,999 | 670,468 | - | 60.2 | 240,860 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.34 per share. | 16 Feb 2021 | 661 | 449,835 | - | 59.3 | 39,224 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 59.34 per share. | 16 Feb 2021 | 1,014 | 674,467 | - | 59.3 | 60,171 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.48 per share. | 16 Feb 2021 | 667 | 675,481 | - | 58.5 | 39,006 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 58.48 per share. | 16 Feb 2021 | 434 | 450,496 | - | 58.5 | 25,380 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 65.01 per share. | 16 Feb 2021 | 75 | 439,634 | - | 65.0 | 4,876 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 64.93 per share. | 11 Feb 2021 | 1,272 | 30,112 | - | 64.9 | 82,591 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2021 | 5,300 | 145,605 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 68.07 per share. | 11 Feb 2021 | 14 | 27,991 | - | 68.1 | 953 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 67.05 per share. | 11 Feb 2021 | 262 | 28,005 | - | 67.0 | 17,567 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 65.99 per share. | 11 Feb 2021 | 1,845 | 28,267 | - | 66.0 | 121,752 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 63.74 per share. | 11 Feb 2021 | 1,460 | 31,384 | - | 63.7 | 93,060 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 62.85 per share. | 11 Feb 2021 | 447 | 32,844 | - | 62.9 | 28,094 | Common Stock |
| Jennifer Lachey | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.30 per share. | 11 Feb 2021 | 5,300 | 33,291 | - | 0.3 | 1,590 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 68.00 per share. | 11 Feb 2021 | 2 | 0 | - | 68 | 136 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 66.19 per share. | 11 Feb 2021 | 295 | 2 | - | 66.2 | 19,526 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 65.35 per share. | 11 Feb 2021 | 216 | 297 | - | 65.4 | 14,116 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.48 per share. | 11 Feb 2021 | 1,000 | 1,000 | - | 0.5 | 480 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 63.10 per share. | 11 Feb 2021 | 175 | 825 | - | 63.1 | 11,043 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 64.17 per share. | 11 Feb 2021 | 312 | 513 | - | 64.2 | 20,021 | Common Stock |
| Claudia Ordonez | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Feb 2021 | 1,000 | 102,211 | - | - | Employee Stock Option (right to buy) | |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.03 per share. | 11 Feb 2021 | 913 | 452,132 | - | 61.0 | 55,720 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 61.03 per share. | 11 Feb 2021 | 1,397 | 677,993 | - | 61.0 | 85,259 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.20 per share. | 11 Feb 2021 | 833 | 453,045 | - | 60.2 | 50,147 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 60.20 per share. | 11 Feb 2021 | 1,278 | 679,390 | - | 60.2 | 76,936 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 67.97 per share. | 11 Feb 2021 | 35 | 453,878 | - | 68.0 | 2,379 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 67.98 per share. | 11 Feb 2021 | 53 | 680,668 | - | 68.0 | 3,603 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 66.65 per share. | 11 Feb 2021 | 206 | 453,913 | - | 66.7 | 13,730 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 66.65 per share. | 11 Feb 2021 | 316 | 680,721 | - | 66.6 | 21,061 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 65.80 per share. | 11 Feb 2021 | 1,575 | 454,119 | - | 65.8 | 103,635 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 65.80 per share. | 11 Feb 2021 | 2,418 | 681,037 | - | 65.8 | 159,104 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 64.87 per share. | 11 Feb 2021 | 952 | 455,694 | - | 64.9 | 61,756 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 64.87 per share. | 11 Feb 2021 | 1,461 | 683,455 | - | 64.9 | 94,775 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.83 per share. | 11 Feb 2021 | 1,526 | 456,646 | - | 63.8 | 97,405 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.79 per share. | 11 Feb 2021 | 270 | 458,172 | - | 62.8 | 16,953 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.87 per share. | 11 Feb 2021 | 30 | 450,930 | - | 63.9 | 1,916 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.85 per share. | 11 Feb 2021 | 46 | 676,148 | - | 63.8 | 2,937 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.14 per share. | 11 Feb 2021 | 531 | 450,960 | - | 63.1 | 33,527 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.14 per share. | 11 Feb 2021 | 814 | 676,194 | - | 63.1 | 51,396 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.52 per share. | 11 Feb 2021 | 641 | 451,491 | - | 62.5 | 40,075 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.52 per share. | 11 Feb 2021 | 985 | 677,008 | - | 62.5 | 61,582 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 62.79 per share. | 11 Feb 2021 | 414 | 687,251 | - | 62.8 | 25,995 | Common Stock |
| Julius Knowles | Director | Sale of securities on an exchange or to another person at price $ 63.83 per share. | 11 Feb 2021 | 2,335 | 684,916 | - | 63.8 | 149,043 | Common Stock |
| Keith Regnante | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2021 | 49,150 | 49,150 | - | - | Employee Stock Option (right to buy) | |
| Jasbir Seehra | Director, Chief Executive Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2021 | 127,200 | 127,200 | - | - | Employee Stock Option (right to buy) | |
| Jennifer Lachey | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2021 | 42,250 | 42,250 | - | - | Employee Stock Option (right to buy) | |
| Claudia Ordonez | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 10 Jan 2021 | 42,250 | 42,250 | - | - | Employee Stock Option (right to buy) | |
| Mary Ann Gray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Dec 2020 | 16,587 | 16,587 | - | - | Stock Option (right to buy) | |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 26,634 | 2,288,151 | - | 50 | 1,331,700 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 6,000 | 155,262 | - | 50 | 300,000 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 14,400 | 1,228,326 | - | 50 | 720,000 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 12,966 | 1,122,768 | - | 50 | 648,300 | Common Stock |
| Ran Nussbaum | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 26,634 | 2,288,151 | - | 50 | 1,331,700 | Common Stock |
| Ran Nussbaum | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 6,000 | 155,262 | - | 50 | 300,000 | Common Stock |
| Ran Nussbaum | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 14,400 | 1,228,326 | - | 50 | 720,000 | Common Stock |
| Ran Nussbaum | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 50.00 per share. | 17 Nov 2020 | 12,966 | 1,122,768 | - | 50 | 648,300 | Common Stock |
| Nima Farzan | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 May 2020 | 8,500 | 8,500 | - | - | Stock Option (right to buy) | |
| Carl L. Gordon | Director | 13 Apr 2020 | 744,612 | 0 | - | - | Series C Preferred Stock | ||
| Carl L. Gordon | Director | 13 Apr 2020 | 744,612 | 744,612 | - | - | Common Stock | ||
| Carl L. Gordon | Director | 13 Apr 2020 | 148,922 | 148,922 | - | - | Common Stock | ||
| Carl L. Gordon | Director | Purchase of securities on an exchange or from another person at price $ 16.00 per share. | 13 Apr 2020 | 375,200 | 1,119,812 | - | 16 | 6,003,200 | Common Stock |
| Carl L. Gordon | Director | 13 Apr 2020 | 148,922 | 0 | - | - | Series C Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 88,460 | 0 | - | - | Series C Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 36,858 | 0 | - | - | Series C Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 79,653 | 0 | - | - | Series C Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 1,363,542 | 1,734,395 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 663,825 | 844,371 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 737,226 | 937,735 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 169,307 | 1,903,702 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 82,425 | 926,796 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 91,538 | 1,029,273 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 68,654 | 68,654 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 163,612 | 2,067,314 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 88,460 | 1,015,256 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 79,653 | 1,108,926 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 36,858 | 105,512 | - | - | Common Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 16.00 per share. | 13 Apr 2020 | 194,203 | 2,261,517 | - | 16 | 3,107,248 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 16.00 per share. | 13 Apr 2020 | 94,546 | 1,109,802 | - | 16 | 1,512,736 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 16.00 per share. | 13 Apr 2020 | 105,000 | 1,213,926 | - | 16 | 1,680,000 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 16.00 per share. | 13 Apr 2020 | 43,750 | 149,262 | - | 16 | 700,000 | Common Stock |
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 1,363,542 | 0 | - | - | Series A Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 663,825 | 0 | - | - | Series A Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 737,226 | 0 | - | - | Series A Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 169,307 | 0 | - | - | Series B-1 Preferred Stock | ||
| Tomer Kariv | Director, Ten Percent Owner | 13 Apr 2020 | 82,425 | 0 | - | - | Series B-1 Preferred Stock |